9:00 am

Online Log In & Coffee Networking

9:50 am Chair’s Opening Remarks

What is Next in Drugging RAS? Navigating the Landscape of G12C & Beyond

10:00 am Which RAS Mutant Will be the Next After KRAS G12C?

  • Darryl McConnell Senior Vice President & Research Site Head Austria , Boehringer Ingelheim

10:30 am Exquisitely Specific Anti-KRAS Biodegraders – Informing Cellular Prevalence of Nucleotide-Loaded States

11:00 am Identification of Novel Covalent Allosteric Binding Pocket for KRAS G12C with Computationally Empowered Workflow

11:30 am

Morning Break & Virtual Speed Networking

12:30 pm Panel Discussion: Precision Medicine – Patient Selection to Ensure Optimal Clinical Translation & Therapeutic Benefit

  • Caroline Phillips Head of Oncology, Redx Pharma
  • Shubham Pant Associate Professor GI Medical Oncology, Department of Investigational Cancer Therapeutics, MD Anderson Cancer Center
  • Darryl McConnell Senior Vice President & Research Site Head Austria , Boehringer Ingelheim
  • Julian Downward Associate Research Director , Francis Crick Institute

1:30 pm

Lunch & Networking

2:30 pm Exploiting Atypical KRAS G12R Mutation to Define KRAS Mutation-Specific Signalling & Therapeutic Vulnerabilities

  • Aaron Hobbs Assistant Professor, Medical University of South Carolina

3:00 pm Discovery of Novel Methods of Targeting Oncogenic KRAS G12D Signalling

3:30 pm

Afternoon Break & Poster Session

Unlocking the Key to Successful Combination & Immune-Oncology Strategies for RAS Targeted Therapeutics

4:30 pm Approaches to Limiting the Development of Tumour Resistance to KRAS G12C Inhibitory Drugs

5:00 pm Exploiting Oncogenic RAS-Dependent Tumour Cell Vulnerabilities to Design New Therapeutics

  • Dafna Bar-Sagi Executive Vice President & Vice Dean for Science, Chief Scientific Officer, NYU Langone School of Medicine

5:30 pm Exploring Data from a Novel Pan-RAS Inhibitor Class

  • Gary Piazza Professor of Pharmacology, Chief of Drug Discovery Research Centre, University of South Alabama Mitchell Cancer Institute

6:00 pm

End of Conference Day One