Chemotype Evolution Platform for Discovering Covalent Inhibitors of KRAS G12C & Beyond
Time: 9:50 am
day: Day Two
Details:
- We will present the development of Chemotype Evolution for rapid, highthroughput identification and advancement of covalent inhibitors
- Challenges faced and overcome in the construction and screening of covalent warhead-fragment libraries will be described
- We will describe the deployment of our approach to identify potent covalent inhibitors of KRAS G12C
