Chemotype Evolution Platform for Discovering Covalent Inhibitors of KRAS G12C & Beyond

Time: 9:50 am
day: Day Two


  • We will present the development of Chemotype Evolution for rapid, highthroughput identification and advancement of covalent inhibitors
  • Challenges faced and overcome in the construction and screening of covalent warhead-fragment libraries will be described
  • We will describe the deployment of our approach to identify potent covalent inhibitors of KRAS G12C