How to Study & Overcome KRAS G12i Resistance

Time: 12:00 pm
day: Day One


• Studying KRASG12C inhibitor resistance using in vitro and in vivo models
• Map the resistance mechanisms in both our in vitro and in vivo settings
• Identification of secondary KRAS mutations by deep mutational screening
• Overcoming KRASG12C inhibitor resistance by combination of G12C inhibitor with SOS1 inhibitor