PROTAC Mediated Degradation of KRAS

Time: 12:00 pm
day: Day Two


  • KRAS PROTACs that employ novel ubiquitin ligase and degrade different KRAS isoforms will be the subject of this talk
  • Current methods for PROTAC discovery are not optimal. Use of PROTAC mediated in-vitro ubiquitination to expedite discovery of novel PROTACs
  • Me too ligase, VHL and Cereblon do not offer specificity for certain targets. Relationship between in vitro and in vivo ubiquitination and PROTAC mediated degradation will be discussed