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Laurent Debussche

Laurent Debussche

Company: Sanofi R&D

Job title: Vice President, Global Head Molecular Oncology Research Therapeutic Area


Sanofi Oncology Research is a global organization which manages a large portfolio of preclinical projects and several collaborations with Academia, Biotechs and Pharmas. It is composed of 2 closely collaborating Therapeutic Areas, Immuno-Oncology and Molecular Oncology, both located in two sites: Cambridge, Massachusetts and Vitry-sur-Seine, France. Dr. Laurent Debussche is V.P. Global Head of Molecular Oncology Research Therapeutic Area since 2016. He joined one of the mother company of Sanofi more than 30 ago and worked from the beginning on cancer molecular targets such as RAS. In 1998, he became a senior Oncology research leader. He contributed to and even directly led several preclinical candidate nominations as well as first-in-human and clinical projects, has built a large Oncology international network and was referred as a “stubborn” cancer scientist in a front page article of 12/22/2012 New York Times issue. He is author of 60+ peer-reviewed scientific publications.


Panel Discussion: Advancing Successful Clinical Translation of RAS Targeted Therapies 2:30 pm

How to translate the promising science and the clear opportunity into safe and effective anti-RAS therapies? Routes for translational success from discovery to clinic: What will be the key factors for generating successful clinical results? What will investors look for in the next few years and what are the major challenges to be overcome in…Read more

day: Day Two

RAS Protein Flexibility or How to Target Cryptic Pockets to Drug the Undruggable Master Oncogene 11:45 am

RAS is a very flexible protein without any apparent druggable pocket which has resisted three decades of efforts to drug it Cryptic or induced pockets can be identified in addition to so-called SII pocket DNA-encoded library approach is a powerful approach to drug cryptic pockets such as SII pocketRead more

day: Day One

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