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Matthew A. Marx

Matthew A. Marx

Company: Mirati Therapeutics

Job title: Vice President, Drug Discovery


Dr. Marx has over 24 years of post-Ph.D. experience in chemistry and drug discovery. Currently Vice President and head of Drug Discovery at Mirati Therapeutics, he is responsible for the creation and progression of small molecules to advance the Mirati research portfolio, overseeing synthetic and medicinal chemistry, structural biology, molecular modeling and DMPK. Prior to Mirati, Dr. Marx led the chemistry department at Takeda California, advancing medicinal chemistry efforts across oncology, immunology and metabolic diseases projects as a member of the site senior leadership team, the global chemistry leadership team and the global oncology research leadership team. Dr. Marx began his industry career in the oncology research group at Pfizer, where he worked in roles of escalating responsibility at the Groton, CT site, ultimately leading that therapeutic area chemistry group.



Panel Discussion: Advancing Successful Clinical Translation of RAS Targeted Therapies 2:30 pm

How to translate the promising science and the clear opportunity into safe and effective anti-RAS therapies? Routes for translational success from discovery to clinic: What will be the key factors for generating successful clinical results? What will investors look for in the next few years and what are the major challenges to be overcome in…Read more

day: Day Two

Discovery and Preclinical Characterization of MRTX1257, a Selective, Covalent KRAS G12C Inhibitor with Oral Activity in Animal Models of Cancer 9:30 am

We have identified a series of orally active, covalent inhibitors of oncogenic mutant KRAS G12C These inhibitors, exemplified by MRTX1257, drive regressions in a series of xenograft and PDX models as single agents A comprehensive translational pharmacology evaluation has identified combination strategies that enhance single-agent activity in certain modelsRead more

day: Day Two

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