Michael Eck

Michael Eck

Company: Department of Biological Chemistry & Molecular Pharmacology Harvard Medical School

Job title: Professor

Seminars:

Live Panel Q&A – Ask the Speakers Your Burning Questions 5:05 pm

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day: Day One

Structural Insights into Pharmacologic Targeting of the RAS/ RAF/MEK/ERK Pathway 4:15 pm

Cryo-EM structures show how BRAF, MEK, and a 14-3-3 dimer or organized in autoinhibited and active states Binding of ATP in the active site of RAF is crucial for maintaining auto inhibition, RAF inhibitors that displace it cause activation RAS can engage autoinhibited RAF complexes without disrupting them Stabilizing autoinhibited RAF Complexes may be an…Read more

day: Day One

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