Poulikos Poulikakos

Poulikos Poulikakos

Company: Icahn School of Medicine at Mount Sinai

Job title: Associate Professor


Targeting Adaptive Resistance to RAS/MAPK-Directed Therapies 11:30 am

Adaptive resistance and RAS/MAPK reactivation limits therapeutic response to RAS/MAPK targeting agents Development of inhibitors targeting components of the RAS/MAPK adaptive machinery (inhibitors of RTKs, SHP2, SOS, dimeric RAF) enables the development of more effective combinatorial therapeutic approaches Effective targeting of components of RAS/MAPK in their native conformations in cells requires elucidating and exploiting allosteric…Read more

day: Day One

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