Company: Weatherall Institute of Molecular Medicine, University of Oxford
Job title: Professor of Molecular Immunology
Prof. Terry Rabbitts is a molecular immunologist who trained at the MRC National Institute for Medical Research, Mill Hill, worked at the MRC Laboratory of Molecular Biology in Cambridge where he was head of the Division of Protein and Nucleic Acid Chemistry, jointly with Cesar Milstein. He now works at the Weatherall Institute of Molecular Medicine (University of Oxford) developing technologies using intracellular antibody fragments and small molecule derivatives, mainly aimed at targeting chromosomal translocation protein products. He was chairman of scientific advisory board of Cambridge Antibody Technology from launch until IPO, and currently advises several start-up biotech companies. He is co-founder of Orbit Discovery and Quadrucept Bio. He is a Fellow of the Royal Society (1987) , a Fellow of the Academy of Medical Sciences (1998) and an EMBO Member (1981). He has been the recipient of the Colworth Medal, the CIBA prize and the Clotten Foundation Prize in recognition for his work on the diversity and rearrangement of human of antibody genes, and the mechanism of chromosomal translocations in cancer aetiology.
Intracellular Antibody Fragments as Starting Points for Drug Discovery and as Macrodrugs for Therapy 4:15 pm
Discovery of novel RAS-binding compounds using intracellular antibody competition in compound library screens for inhibitors on protein-protein interactions Using intracellular antibodies screening methods to develop RAS isoform specific macromolecular drugs (macrodrugs) Employing intracellular antibody macrodrugs to invoke KRAS-specific proteosome degradation in KRAS-mutant cellsRead more
day: Day One